Modification and application of the third-generation adenovirus vectors
- VernacularTitle:第三代腺病毒载体的改良与应用
- Author:
Lin CHEN
;
Xuchao XUE
- Publication Type:Journal Article
- Keywords:
third-generation adenovirus;
genetic vectors;
helper viruses
- From:
Academic Journal of Second Military Medical University
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Adenovirus as gene transfer vector is characterized by high transfection efficiency,high titer,good stability in target cells and low pathogenicity,and has been widely used in gene therapy.Compared to first-and second-generation adenovirus vectors,the third-generation adenovirus vectors have unique advantages for gene therapy because of their low immunogenicity and high capacity.However,the clinical application of the third-generation adenovirus vectors is hampered by the existance of helper contamination and difficulties in their large-scale production.
