Expression of chemokine receptor CCR5 in human follicular thyroid carcinoma
- VernacularTitle:CC趋化因子受体5在滤泡状甲状腺癌中的表达
- Author:
Xuelian GONG
;
Baoyu GUO
- Publication Type:Journal Article
- Keywords:
CC chemokine receptor 5;
thyroid neoplasms;
adenocarcinoma,follicular;
CCL3;
CCL5
- From:
Academic Journal of Second Military Medical University
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expression of chemokine receptor CCR5 in follicular thyroid carcinoma and the serum level of CCR5 ligand,so as to assess the role of CCR5 in progression and metastasis of follicular thyroid carcinoma.Methods:Fifteen samples of follicular thyroid carcinoma,17 samples of follicular thyroid adenoma and 12 adjacent normal samples were analyzed immunohistochemically for CCR5 expression.The sera concentrations of CCL3,CCL4 and CCL5 were measured by ELISA in all patients.Results:CCR5 was positive in follicular thyroid carcinoma samples,with the positive rate being 73.33%,and was not detected in the follicular thyroid adenoma and the normal samples(P
