Effect of arterial baroreflex on survival rate of rats with cecal ligation and puncture-induced sepsis
- VernacularTitle:动脉压力感受性反射对盲肠结扎穿孔致脓毒症大鼠生存率的影响
- Author:
Keyong SHI
;
Xiujuan MA
;
Yinglin CAO
;
Wei ZHANG
;
Fuming SHEN
- Publication Type:Journal Article
- Keywords:
cecal ligation and puncture;
sepsis;
baroreflex;
sinoaortic denervation;
survival analysis
- From:
Academic Journal of Second Military Medical University
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of arterial baroreflex(ABR)on survival rate of rats with cecal ligation and puncture(CLP)-induced sepsis.Methods:Male Sprague-Dawley rats were divided into 2 groups:sham-operated rats(n=22)and sinoaortic denervated(SAD)rats(n=22).Four weeks after SAD rats were subjected to CLP-induced sepsis,the blood pressure and heart period(HP)were monitored for 12 hours in conscious state and the survival of rats was observed.Results:Both the diastolic and systolic blood pressue gradually decreased after CLP;the HP shortened first and then drastically prolonged until the death of rats.At 12 h after CLP the survival rate of SAD rats was lower than that of the sham-operated rats(59% vs 86%).Significant differences were found between the Kaplan-Meier survival curves of the rats in 2 groups(P
