Influence of hypoxia on leptin expression in C57BL/6J mice
- VernacularTitle:急性缺氧诱导C57BL/6J小鼠瘦素表达增加
- Author:
Xi LIU
;
Yamei WU
;
Ling XU
;
Chao TANG
;
Yinbao ZHONG
- Publication Type:Journal Article
- Keywords:
hypoxia;
leptin;
respiration
- From:Journal of Third Military Medical University
2003;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of hypoxia on leptin expression in serum,CSF and brain tissue of C57BL/6J mice.Methods C57BL/6J mice were divided into 3 groups:the normal control,24-hour hypoxia group and 48-hour hypoxia group.The latter two groups exposed to hypoxia in the man-made auto pressure and hypoxia control cabin(XQ-I).Radioimmunoassay was used to detect the leptin level.Results The leptin level in the serum,CSF and brain tissue of mice exposed to hypoxia were higher than that of normal control,but no difference was found between 24-hour hypoxia group and 48-hour hypoxia group.Conclusion Hypoxia probably induces the increasing of leptin expression in fat tissue,as well as in the central nervous system.
