Clinical study of mycophenolate mofetil treatment in HBV associated glomerulonephritis
- VernacularTitle:霉酚酸酯治疗乙型肝炎病毒相关性肾炎的临床观察
- Author:
Guangyu ZHOU
;
Xuesong SU
;
Detian LI
- Publication Type:Journal Article
- Keywords:
Mycophenolate mofetil;
Hepatitis B virus-associated glomerulonephritis
- From:
Chinese Journal of Practical Internal Medicine
2006;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and the adverse effect of mycophenolate mofetil(MMF)in HBV associated glomerulonephritis.Methods Twenty patients with HBV-GN diagnosed by renal biopsy were treated with MMF.The initial dosage of MMF was 1.5 g/d.The dosage was reduced to 1.0 g/d when 24 h excretion of urinary protein decreased to 0.5 g/d.Blood routine test,hepatic and renal function,plasma albumin,serum triglyceride and cholesterol,24 h urinary protein excretion,HBV DNA were performed before and after 2,3,6,9 months' treatment.Results Twenty-four-hour urinary protein excretion was significantly reduced by the treatment with mycophenolate mofetil(P