Research on the Relationship Between the Changing Law of the Cytokines and Tumor-related Fatigue in Gastric Carcinoma
- VernacularTitle:胃癌细胞因子变化规律与肿瘤相关性乏力关系研究
- Author:
Huili MA
;
Weixi SHEN
;
Yumei LIU
;
Qingxia FAN
- Publication Type:Journal Article
- Keywords:
Tumor-related fatigue;
Gastric carcinoma;
Gene chip;
TNF-?;
TGF-?1
- From:
Journal of Medical Research
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between the changing law of cytokine gene expression profile and tumor-related fatigue and to verify the preliminary theory conclusion that the pathogenesis of tumor-related fatigue may be due to the up-regulation of the TNF,TGF-?,etc.Methods The changing characteristics of gene expression profile of cytokines were studied in peripheral blood mononuclear cells samples with gene chip.Results The gene expression level of TNF-? and TGF-?1 was up regulated.Conclusions The experimental results conform to the theory research conclusion and show that the pathogenesis of tumor-related fatigue due to the up-regulation of the gene expression level of TNF and TGF-?.
