An Clinical Studys of Photodynamic Therapy Different on Malignant Tumors
- VernacularTitle:光动力治疗恶性肿瘤临床研究
- Author:
Honwu WANG
- Publication Type:Journal Article
- Keywords:
Photodynamic therapy;
Lung cancer;
Digestive tract cancer;
Brain gliomas
- From:
Journal of Medical Research
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The effects of photodynamic therapy(PDT)were observed in different malignant tumors.Methods Photosan(2mg/kg)was intravenously given in 45 cases of 20 central lung cancer,8 recurrent brain gliomas,6 esophagus cancer,2 stomach cancer,2 colum cancer,5 the others.After 48 and 72 hours later,PDT(He-Ne Gas Laser,630nm)was performed respectively with 800~1000mW,energy density 200~300J/cm(or 300J/cm2).More than 1 cm of normal tissue around the tumor was treated by laser in 10~20 minutes.Results Tumor necrosis could be found in next day of PDT,which showed that heavy white blanket covered the tumor accompanied by severe edema around the tumor.The volume of lumen cancer should be enlarged after 1 week of PDT.Necrosis and cavities could be discovered under light microscopy.The efficiency was 100% in all patients after 1 month of PDT.Conclusions PDT is a minimal,targeted and perspective therapy to tumors.
