Apoptosis and Expression of Caspase in Peripheral-blood Lymphocyte(PBLC) of Systemic Lupus Erythematosus(SLE) Patients
- VernacularTitle:SLE患者外周血淋巴细胞凋亡及Caspase表达研究
- Author:
Aifang XU
;
Zhiliang XU
- Publication Type:Journal Article
- Keywords:
Systemic lupus erythematosus(SLE);
Apoptosis;
Peripheral-blood lymphocyte(PBLC);
Caspase
- From:
Journal of Medical Research
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the apoptosis of PBLC in SLE patients and the roles of caspase in the pathogeneses of SLE.Methods PBLC apoptosis was evaluated by vitro cell culture in 25 patients with SLE(11 active stage,14 catabasis),and 18 controls.The expression of caspase of PBLC was also detected by Western blot.Results In SLE,compared with controls,the apoptosis of PBLC were reduced before cell culture while those were increased after culture 24 and 48hrs.Expressions of caspase-2,3 in active stage patients were lower than those of catabasis group and controls.Conclusions Abnormal PBLC apoptosis results in decreasing Caspase2,3 in SLE patients.
