Relationship Between the Expression of TIMP-2 and VEGF in Squamous Cell Carcinoma of Larynx and the Prognosis of Patients with Laryngnocarci Noma
- VernacularTitle:TIMP-2和VEGF表达与喉癌预后关系
- Author:
Xiaolin CAO
;
Rujun XU
;
Zhenghu WU
;
Xiaoyang YUAN
;
Yang ZHANG
- Publication Type:Journal Article
- Keywords:
Laryngeal neoplasma;
Carcinoma;
Squamous cell;
Vascular endothelial growth factor;
Tissue inhibitor of metalloproteinase;
Prognosis
- From:
Journal of Medical Research
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between expression of vascular endothelial growth factor(VEGF)and tissue inhibitor of metalloproteinase 2(TIMP-2)and prognosis of patients with laryngeal squamous cell carcinoma.Methods The expression of VEGF and TIMP-2 were measured in 38 specimen of LSCC and 19 specimens of normal laryngeal tissue adjacent to the tumors with EnVision immunohistochemical technique,follow-up for 3~5 years after operation local relapse occurred in four cases,cervical nodular metastasized occurred in fwo cases and pneumonic metastasis occurred one case.Results The expression level of two marks in primary tumors was significantly higher than that in pericancerous tissues(P
