Efficacy of three-dimensional conformal radiotherapy combined with hepatic arterial chemoembolization for patients with primary hepatic cancer
- VernacularTitle:原发性肝癌三维适形放疗联合肝动脉栓塞化疗的近期疗效观察
- Author:
Gong LI
;
Youxian HOU
- Publication Type:Journal Article
- Keywords:
liver neoplasms;
radiotherapy,conformal;
chemoembolization,therapeutic
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of three-dimensional conformal radiotherapy(3D-CRT) combined with transcatheter hepatic arterial chemoembolization(TACE) for patients with primary liver cancer.Methods From July 2003 to July 2006,followed by transcatheter hepatic arterial chemoembolization(TACE,mitomycin + 5-fluorouracil + pirarubicin) 3 times in 6 weeks,59 patients with primary hepatic cancer received noncoplanarity multifield 3D-CRT by using Leibinger three-dimensional stereotactic conformal radiotherapy planning system,Varian 600C/D 6MeV X liner accelerator and multileaf collimator at a dose of 60-65Gy/9-11 fractions/15-22 days.Results Of 59 patients,58 cases received a complete course of 3D-CRT combined with TACE.CT results showed that the rates of complete response(CR),partial response(PR),no change(NC) and progression(PD) rate were 57.6%(34/59),35.6%(21/59),3.4%(2/59) and 3.4%(2/59),respectively.Overall response rate(CR+PR) was 93.2%(55/59).Jaundice occurred one week after treatment in one patient,who died of acute hepatic function failure.No serious adverse effects or intoxication were found in the remaining 58 patients.Conclusions The combination of 3D-RCT with TACE was an effective treatment for patients with primary hepatic cancer.
