The effects of midazolam and propofol on liver against hypoxia/reoxygenation injury in rats
- VernacularTitle:对比观察咪达唑仑和异丙酚对大鼠肝脏缺氧复氧损伤的影响
- Author:
Yingjie SUN
;
Guangjie GAO
;
Tiezheng ZHANG
- Publication Type:Journal Article
- Keywords:
midazolam;
propofol;
hypoxia/reoxygenation;
liver;
isoprostanes;
nitric-oxide synthase;
nitric oxide
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the preventive effects of midazolam and propofol on liver against hypoxia/reoxgenation(H/R) injury in rats.Methods Twenty-four Wistar rats of both sexes weighing 200-250g were randomized into four groups:control group(group A),hypoxia/reoxygenation(group B),H/R + midazolam(group C) and H/R + propofol(group D).The 8-iso-prostaglandin F2?(8-iso-PGF2?) levels in the hepatic tissue were determined by enzyme-linked immunosorbent assay(ELISA).The contents of nitric oxide(NO) and the activity of nitric-oxide synthase(NOS) in hepatic tissue were determined by biochemistry methods.Results After hypoxia and reoxgenation injury in rats,the 8-iso-PGF2? level of hepatic tissue in group B was significantly higher than that in group A(P
