The influence of fibrin glue and glutamine on the healing of colon anastomoses after immediate postoperative intraperitoneal administration of 5-fluorouracil
- VernacularTitle:生物蛋白胶和谷氨酰胺对腹腔化疗后结肠吻合口愈合影响的研究
- Author:
Lei SHI
;
Songyan ZHANG
;
Qiang CHI
- Publication Type:Journal Article
- Keywords:
Intraperitoneal chemotherapy;
Fibrin glue;
Glutamine;
Colonic healing
- From:
Parenteral & Enteral Nutrition
1997;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effects of fibrin glue(FS) and glutamine(Gln) on the healing of colon anastomoses after immediate postoperative intraperitoneal administration of 5-fluorouracil.Methods: Thirty two female Wistar rats were randomized into four groups.After resection of a 1-cm segment of the transverse colon,an end-end sutured anastomosis was performed.Then the rats were divided into control group,5-FU group,FS group,and Gln group.All rats were killed on the 8th postoperative day and the anastomoses were examined microscopically.The bursting pressure measurements were recorded and anastomoses were graded histologically.Results: The adhesion formation score was significantly higer in the rats of the 5-FU group than in the other groups.Bursting pressures were also significantly lower in the 5-FU group than in the other groups.Conclusion: The immediate postoperative intraperitoneal administration of 5-FU inhibited wound healing.However,FS and Gln can improve early healing of colon anastomoses after immediate postoperative intraperitoneal administration of 5-fluorouracil.
