Proliferation and apoptosis in stage-Ⅰ NSCLC and their clinical implications
- VernacularTitle:Ⅰ期非小细胞肺癌细胞增殖与凋亡及其临床意义研究
- Author:
Shijie ZHOU
;
Shaofa XU
;
Haiqing ZHANG
- Publication Type:Journal Article
- Keywords:
Lung cancer;
Proliferation;
Apoptosis;
Prognosis;
Immunohistochemistry;
TUNEL;
Ki67
- From:
Chinese Journal of Practical Internal Medicine
2006;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the proliferation and apoptosis in stage-ⅠNSCLC and their prognostic implications.Methods Immunohistochemical technology and TUNEL assay was applied to detect proliferation and apoptosis in 118 lung cancer tissues and 30 normal lung tissues as controls.Results Proliferation Index(PI)was up-regulated in lung cancer tissues compared with that in normal lung tissues and was closely related to T-staging,differentiation and smoking.Apoptotic Index(AI)was up-regulated in lung cancer tissues compared with that in normal lung tissues and was closely related to T-staging.PI was not related to AI in stage-ⅠNSCLC.The patients with high PI had a shorter 5-year survival than those with low PI(33.57% and 73.12%,P=0.0001),and the patients with low AI had a shorter 5-year survival than those with high AI(41.48% and 68.80%,P=0.008).Multivariate analysis showed that PI was a significantly independently predictive factor for patients with stage-ⅠNSCLC(RR=2.473,95%CI:1.278~4.784,P=0.007).Conclusion Stage-ⅠNSCLC is a subgroup with high proliferation and apoptosis.Proliferation plays a more important role in stage-ⅠNSCLC.The assessment of proliferation and apoptosis may provide new insight into prognosis and adjuvant treatment for stage-Ⅰ NSCLC.
