Recent progress in research of protective effects of erythropoietin on cerebral ischemia
- VernacularTitle:促红细胞生成素对脑缺血的保护作用研究进展
- Author:
Yueping YU
;
Yilu YE
- Publication Type:Journal Article
- Keywords:
erythropoietin;
cerebral ischemia;
neuroprotection
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
It has been proved that erythropoietin has neuroprotective effect and therapeutic action on cerebral ischemia in vivo and in vitro. The mechanisms of these actions may be involved in anti-exitotoxicity of aminoglutaric acid, regulating the synthesis of nitric oxide, antioxidation, antiinflammatory, inhibiting neuron apoptosis, accelerating angiogenesis, neurogenesis, neurotrophy and others. In addition, exogenous erythropoietin can enter brain tissue through blood-brain barrier and exert neuroprotection. So it is indicated that erythropoietin can be expected to be a new drug to prevent and treat cerebral ischemia.
