Effect of nonselective endothelin receptor antagonist on local angiotensin system of myocardial hypertrophy
- VernacularTitle:非选择性内皮素受体拮抗剂对肥厚心肌局部血管紧张素系统的影响
- Author:
Xiong PENG
;
Jianghua REN
;
Maoyin CAO
;
Xun WANG
- Publication Type:Journal Article
- Keywords:
endothelin;
pd142893;
angiotensin Ⅱ;
angiotensin-convertion enzyme;
angiotensin receptor-1
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the effect and mechanism of endothelin receptor antagonist on local angiotensin system of hypertrophic myocardial tissue. METHODS: Twenty four rats were randomly divided into 3 groups, control group (CG), hypertrophy group (HG) and endothelin receptor antagonist group (EG). The ratios of left ventricle weight to body weight (LVW/BW) and left ventricle weight to heart weight (LVW/HW) were measured to reflect myocardial hypertrophy. Protein expression of AT1R was detected by immunohistochemistry. The concentration of Ang Ⅱ was determined by ria. Activity of ACE was examined by spectrophotometry. A piece of myocardial tissue was observed in light microscope after HE or VG dyeing. RESULTS:(1) In comparison to CG, LVW/BW, LVW/HW, ACE activity, the concentration of Ang Ⅱ and the expression of AT1R of HG were increased significantly (P
