Research progress on the acid-sensing ion channel 1a
- VernacularTitle:酸感受离子通道亚基1a的研究进展
- Author:
Qinge JIN
;
Jianquan ZHENG
- Publication Type:Journal Article
- Keywords:
acid-sensing ion channel 1a;
ischemia;
acidosis
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Acid-sensing ion channels (ASICs), which are activated by extracelluar H+, are H+-gated cation channels. At present, seven subunits of ASICs family have been identified. Numerous studies revealed that ASIC1a plays important roles in synaptic transmission and plasticity,spatial learning and memory, nociception, as well as cerebral ischemia under physiological and pathological conditions. This review concerns the latest research about ASIC1a to promote the understanding of its physiological and pathological functions.
