Adult brain angiogenesis and depression
- VernacularTitle:成年脑血管新生与抑郁症
- Author:
Liming ZHANG
;
Yunfeng LI
;
Zehui GONG
- Publication Type:Journal Article
- Keywords:
depression;
angiogenesis;
vascular endothelial growth factor;
neurogenesis;
stress
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Down-regulation of adult hippocampal neurogenesis has been regarded as one of the important biological and cellular basis of depression. Recent studies have shown that there is a close correlation between neurogenesis and angiogenesis. Several angiogenesis factors, especially vascular endothelial growth factor (VEGF), play a vital role on angiogenesis. They not only have the neurotrophic and neuroprotective effects, but also up-regulate hippocampal neurogenesis. Thus,VEGF may be involved in the occurrence and treatment of major depression. This article reviews current understanding of the relationship between adult brain angiogenesis and depression.
