Correlation between MDR1 genetic polymorphism and prognosis in acute leukemia
- VernacularTitle:MDR1基因多态性及表达与急性白血病患者预后相关性的研究进展
- Author:
Dan WANG
;
Xiaoyan KE
;
Yongfang HU
- Publication Type:Journal Article
- Keywords:
acute leukemia;
MDR1 genetic polymorphism;
complete remission;
free-event survival;
overall survival
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Multidrug resistance is a common form of drug resistance of tumors and one main reason for chemotherapy′s failure and recrudescence of acute leukemia. In recent years,substantial studies addressed the different aspects about MDR1,including MDR1 genetic polymorphism,mRNA/protein expression as well as the function of its coding protein (P-gp).This paper reviewed recent advances about the relation between MDR1 genetic polymorphism and acute leukemia prognosis with the aim to improve acute leukemia curing and chemotherapy outcome evaluating in China.
