Protective effect of non-mitogenic haFGF on cerebral ischemia-reperfusion injury in mice
- VernacularTitle:非促分裂型haFGF对小鼠脑缺血/再灌注损伤的保护作用
- Author:
Yuzhi TAN
;
Sa CAI
;
Xiaokun LI
;
Feng LIU
;
Hualiang HU
- Publication Type:Journal Article
- Keywords:
non-mitogenic human acidic fibroblast growth factor (nm-haFGF);
cerebral ischemia-reperfusion injury;
learning and memory;
nitric oxide
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the protective effect of non-mitogenic human acidic fibroblast growth factor (nm-haFGF) on cerebral ischemia-reperfusion injury in mice. Methods Cerebral ischemia-reperfusion model was made by ligating bilateral carotid for 20 minutes in mice. These mice were randomly divided into model group( iv NS), two doses of nm-haFGF (iv 25、50 ?g?kg-1) groups, rhaFGF group(iv 50 ?g?kg-1) and sham- operated group. Step down test and Y-type electric maze were used to examine the effect of nm-haFGF on learning and memory of mice, then Even′s Blue(EB) level and NO level in brain of these mice were measured. Results The nm-haFGF significantly decreased numbers of errors of mice in 5 min in step down test and in Y-type electric maze test; EB and NO levels in brain of these mice were lower than those of model group respectively. Conclusion The nm-haFGF can protect cerebral ischemia-reperfusion injury in mice.
