Effects of total flavones of rhododendra (TFR) on bioelectricity of ventricular myocytes in guinea pig
- VernacularTitle:杜鹃花总黄酮对豚鼠心室肌细胞生物电的影响
- Author:
Yifei FAN
;
Dehu KONG
;
Zhiwu CHEN
;
Shan GAO
- Publication Type:Journal Article
- Keywords:
TFR;
bioelectricity;
ventricular myocytes;
guinea pig
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the effect of total flavones of Rhododendra(TFR)on bioelectricity changes of ventricular myocytes in guinea pigs. Methods Conventional microelectrode technique was used to record action potentials (AP) , resting potentials (RP) and effective refractory period (ERP). Results TFR 25,50 mg?L-1 decreased the action potential duration at 50%,90% repolarization (APD50,APD90) while TFR 100,200,400 mg?L-1 prolonged APD50 and APD90Significantlg. TFR 200,400 mg?L-1markedly decreased action potentials amplitude (APA) and velocity maximum of depolarization (Vmax). TFR 400 mg?L-1decreased resting potential. TFR 200 mg?L-1 prolonged ERP. Conclusion TFR may antagonize Ca2+ inward flow at lower concentration and block K+ inward flow at higher concentration.
