Radiofrequency ablation for larger hepatocellular carcinomas
- VernacularTitle:射频消融在较大原发性肝癌中的应用
- Author:
Bo ZHAI
- Publication Type:Journal Article
- Keywords:
catheter ablation;
liver neoplasms;
carcinoma,hepatocellular
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the treatment outcome of percutaneous image-guided radiofrequency ablation(RFA)for larger hepatocellular carcinomas(with the maximal diameter longer than 4 cm)and to summarize our experience.Methods:From December,1999 to March,2007,441 patients with larger hepatocellular carcinomas,who had missed the best time for surgery, received RFA treatment in our department.The maximal diameter of the tumor was 4-8.2 cm,with a mean of(4.6?0.63)cm. The patients were followed up and the necrosis of the tumor,complication,local recurrence and survival of patients were observed.Results:The complete necrosis rate of tumors was 72.9%.The rate of RFA-associated complication was 20.9% and the rate of severe complication was 9.5%.Seven patients died of RFA.Valid follow-up data of 359 patients were obtained, including 379 tumors with diameter longer than 4 cm.A total of 302 tumors were completely necrotic and 130 of them had recurrence,with a recurrence rate of 43.0%.For patients with a tumor diameter of 4-5 cm,the 1-year,3-year,and 5-year survival rates were 78.2%,48.1%s,and 17.6%,respectively,with a median survival period of 27 months;for patients with a tumor diameter of 5-6 cm,the rates were 66.3%,36.4% and 9.7%,respectively,with a median survival period of 18 months;for patients with a tumor diameter longer than 6 cm,the rates were 53.6%,28.1%,and 0,respectively,with a median survival period of 11 months.Conclusion:RFA is an effective treatment for patients with larger HCC who are not suitable for surgery,but the patients should be selected according to the indications.