Association between serotonin 4 gene polymorphisms and attention deficit hyperactivity disorder comorbid or not comorbid disruptive behavioral disorder
- VernacularTitle:5-羟色胺4受体基因多态与共患破坏性行为障碍的儿童注意缺陷多动障碍的相关性
- Author:
Jun LI
;
Yufeng WANG
;
Rulun ZHOU
;
Li YANG
;
Haobo ZHANG
;
Bing WANG
- Publication Type:Journal Article
- Keywords:
Attention deficit and disruptive behavior disorders;
Receptors,serotonin;
Genes;
Tansmission disequilibrium;
Haplotype
- From:
Journal of Peking University(Health Sciences)
2004;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
T were genotyped by restriction fragment length polymorphism analysis.Transmit/disequilibrium test and haplotype analysis were used to test the association of the three polymorphisms with ADHD comorbid or not comorbid DBD separately.Results:Haplotype T/G/T showed tendency of overtransmission(?2=3.470,P=0.062) to probands of ADHD with DBD, while haplotype C/G/T(?2=4.568,P=0.032) and C/G/C(?2=5.333,P=0.021) were undertransmitted to probands of ADHD without DBD,No biased transmissions of any allele were found in families with probands of ADHD with and without DBD.Conclusion:whether ADHD comorbid DBD or not comorbid DBD makes difference at the level of HTR4 gene polymrohisms.