Association of ER? expression with the clinical pathologic indexes and prognostic biomarkers of breast cancer
- VernacularTitle:乳腺癌雌激素受体?表达与临床病理及预后标志物的关系
- Author:
Yan ZHOU
;
Yi ZHANG
;
Yan LIANG
;
Jun JIANG
- Publication Type:Journal Article
- Keywords:
breast neoplasm;
estrogen receptor;
prognosis
- From:Journal of Third Military Medical University
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the association of ER? expression with the expression of hormonal receptor and prognostic biomarkers.Methods The expressions of ER?,ER?,PR,Ki-67,HER-2/neu and p53 were detected in tissue samples from 109 breast cancer patients by immunohistochemistry on tissue microarray slides.The histologic grade,tumor size and lymph node metastasis status of 109 cases of breast cancer were recorded and served as comparison indexes.Results ER? was expressed in benign epithelium and stroma cells,and breast cancer cells in 59% breast cancer tissues of different histologic types.ER? was coexpressed with ER? in 45% breast cancer tissues.ER? expression was found a statistically significant association with HER-2/neu(P
