INFLUENCE OF ANGIOTENSIN CONVERTING ENZYME INHIBITORY PEPTIDES ON THE EXPRESSION OF eNOS,iNOS,ET-1 mRNA IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS
- VernacularTitle:降血压肽对人脐静脉内皮细胞eNOS、iNOS 、ET-1 mRNA表达的影响
- Author:
Qiong LUO
;
Shimin LI
;
Dong LIU
;
Fang LIU
;
Jun YAN
;
Zhuoneng LI
- Publication Type:Journal Article
- Keywords:
angiotensin converting enzyme inhibitory peptides;
human umbilical vein endothelium cell;
nitric oxide synthase;
endothelin
- From:
Acta Nutrimenta Sinica
1956;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective and Method: To study the influence of angiotensin converting enzyme inhibitory peptides (ACEIP) on the expression of eNOS, iNOS, ET-1 mRNA in cultured human umbilical vein endothelial cells by semi-quantitative reverse transcription-polymerase chain reaction(RT-PCR) method and then investigate its mechanism. Results: Campared with the control, the expression of ET-1 and iNOS was lower and the expression of eNOS was higer in different ACEIP groups. Conclusion: The antihyertensive function of ACEIP partly depended on the its effect to lessen the expression of ET-1,iNOS and induce the expression of eNOS in cultured human umbilical vascular endothelial cells.
