Expression and Clinical Significance Of Selenoprotein-P In The Tissues of Colorectal Cancer
- VernacularTitle:硒蛋白-P在大肠癌组织中表达及其临床意义
- Author:
Xinyu BI
;
Jianqiang CAI
;
Yongfu SHAO
;
Susheng SHI
;
Jianguo YANG
;
Chen LIN
- Publication Type:Journal Article
- Keywords:
Selenoprotein P;
Colorectal cancer;
Tissue microarray;
Immunohistochemistry
- From:
Journal of Medical Research
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the effect of selenoprotein P (SeP) on occurring and developing of colorectal cancer and its clinical significance by detecting the expression of SeP in adjacent mucosa of colorectal cancer, and in the cancer, metastatic lymph node and metastasis hepatic tissues.Methods Tissue microarray was constructed, the expression of SeP in adjacent mucosa of colorectal cancer, and in the cancer, metastatic lymph node and metastasis hepatic tissues were detected by means of immunohistochemistry.Results The positive rate of SeP were 48.4%,69.5%,66.7% and 61.5% in adjacent mucosa, tumor cell, lymph node metastasis and hepatic metastasis. The expression of adjacent mucosa was significantly lower than that in other three sites(?2=16.53,P
