Effects of Sodium 2,3-Dimercapto-1-propanesulfonate (DMPS) on ET-1 During Experimental Myocardial Ischemia-reperfusion Injury
- VernacularTitle:二巯基丙磺酸钠对兔急性心肌缺血再灌注损伤血清ET-1的影响
- Author:
Haiyan ZHANG
;
Lingwen LI
;
Junyan CHENG
- Publication Type:Journal Article
- Keywords:
DMPS;
ET-1;
I/R Injury
- From:
Journal of Medical Research
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of DMPS on ET-1 during experimental myocardial ischemia-reperfusion (I/R) injury.Methods 20 New Zealand rabbits were randomly assigned to 2 groups: I/R group and DMPS protection group with 10 in each group. The blood sample was obtained through vien at different time (5 min before ischemia, the end of the ischemia period and 0.5h, 1h, 2h, 4h, 6h after reperfusion ) in each group.The serum concentrations of ET-1 were detected with radioimmunology method. Results The levels of ET-1 of serum and cardiac tissues increased after ischemia and reperfusion, and were significant different compared with that before ischemia(P0.05).Conclusions The changes of ET-1 were significant when myocardial I/R. DMPS may effectively effect the levels of ET-1 after myocardial ischemia and during I/R injury,and have protecfion of myocardium from ischemia and reperfusion injury.
