IN VITRO INHIBITORY EFFECT OF INTERFERON ON SIMULATED GRANULOMA FORMATION BY EGGS OF SCHISTOSOMA MANSONI
- VernacularTitle:干扰素在体外对模拟的曼氏血吸虫虫卵肉芽肿的抑制作用
- Author:
Wucheng ZHANG
- Publication Type:Journal Article
- From:
Chinese Journal of Parasitology and Parasitic Diseases
1987;0(02):-
- CountryChina
- Language:Chinese
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Abstract:
The effect of gamma interferon on the simulated granuloma formation induced by the eggs of Schistosoma mansoni was observed using a model of SEA-polyacrylamide beads and mouse spleen cells in vitro. The results showed that interferon at the concentration of 0.1~10U/ml could not affect significantly the granulomatous response of the spleen cells of unimmunized mice (Table 1); but at the concentration of 10-100U/ml it could inhibit significantly the response of the spleen cells of immunized mice (Table 2). The mechanism of the inhibition is probably due to the suppression of T helpers in the present study.
