Comparison on the efficacy of dimethyl sulphoxide and hyaluronidase in the treatment of skin damage caused by docetaxel extravasation in rats
- VernacularTitle:二甲基亚砜、透明质酸酶治疗多西紫杉醇外渗性大鼠皮肤损伤
- Author:
Qicong ZHU
;
Rongcheng LUO
;
Jingxia MIAO
- Publication Type:Journal Article
- Keywords:
dimethyl sulfoxide;
hyaluronidase;
docetaxel;
extravasation of diagnostic and therapeutic materials
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The purpose of present study was to compare the efficacy of topical dimethyl sulfoxide(DMSO),intralesional hyaluronidase(HAase)and intralesional HAase plus topical DMSO on skin damage caused by docetaxel extravasation in a rat model.Methods After the establishment of animal model of docetaxel extravasation on each hind limb in 30 SD rats,the animals were assigned randomly into 6 groups with 5 rats for each group:topical DMSO group(TD),intralesional HAase group(IH),IH plus TD group(IH+TD),topical normal saline group(tNS),intralesional NS group(iNS),and control group(C).The extent of skin damage and the healing time were observed and compared.Results The extent of skin damage was different among the 6 groups:severer skin damage was seen in tNS,iNS and C groups compared with TD,IH and IH+TD groups.The healing time was significantly shorter in TD group than in both tNS and C groups [(19.10?2.13)d vs(23.70?2.41)d and(25.70?2.26)d,P
