Effect of rofecoxib on expressions of VEGF and inducible NOS in human gastric carcinoma tissues established in nude mice by orthotopic transplantation
- VernacularTitle:罗非昔布对裸鼠人胃癌原位种植瘤组织中血管内皮生长因子和诱导型一氧化氮合酶表达的影响
- Author:
Yongqiang SUN
;
Qiang WANG
;
Guojing ZHENG
;
Xi SUN
- Publication Type:Journal Article
- Keywords:
rofecoxib;
gastric carcinoma;
orthotopic transplantation;
vascular endothelial growth factor;
inducible nitric oxide synthase
- From:Journal of Third Military Medical University
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the inhibitory effect of rofecoxib in human gastric carcinoma tissues established in nude mice by orthotopic transplantation through the expressions of vascular endothelial growth factor (VEGF) and inducible nitric oxide synthase (iNOS). Methods After the models of human gastric carcinoma in nude mice by orthotopic transplantation were established, rofecoxib was administered intragastrically. The expressions of VEGF and iNOS were evaluated in the local tumors by Envision immunohistochemical method. Results The expression of VEGF protein in isotonic saline group, rofecoxib group and combination group were 81.25%, 61.25%, and 35.00% respectively.There was significant difference between rofecoxib group and isotonic saline group, and so was rofecoxib group and combination group (P
