Expression and clinicopathologic significance of PI3K and p-Akt in laryngeal squamous cell carcinoma
- VernacularTitle:PI3K、p-Akt蛋白在喉鳞癌中的表达及临床意义
- Author:
Dazhi YANG
;
Changyou JI
- Publication Type:Journal Article
- Keywords:
laryngeal neoplasms;
immunohistochemestry;
PI3K;
Akt
- From:Journal of Third Military Medical University
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of phosphoinositide 3-kinase (PI3K) and protein kinase B (Akt) and their role in pathogenesis in laryngeal squamous cell carcinoma. Methods Immunohistochemical S-P method was used to detect the expression of PI3K and p-Akt in 40 paraffin-embedded human laryngeal squamous cell carcinoma, 20 cases of polyp of vocal cords and 20 cases of laryngeal papilloma. All the samples were stained by HE method to confirm their pathologic characteristics. Positive rates of PI3K and p-Akt were evaluated by microscopy. Results PI3K and p-Akt showed low expression in the polyp tissues of vocal cords, while they were of significantly higher expression in laryngeal squamous cell carcinoma (P
