Distribution of Toll-like receptor 2 and 4 in human urinary tract
- VernacularTitle:人尿路上皮细胞TLR2和TLR4分布情况研究
- Author:
Huachao XU
;
Gensheng LU
;
Qinghua ZHANG
- Publication Type:Journal Article
- Keywords:
epithelium;
toll-like receptor;
urinary tract infection
- From:Journal of Third Military Medical University
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mRNA expression of Toll-like receptor (TLR) 2 and 4 in human urinary tract epithelium. Methods The epithelial cells of nephric tubule, pelvis, ureter and bladder were cultured in vitro, and their mRNA expressions of TLR2 and TLR4 were measured by RT-PCR. Results The mRNA expression of TLR2 in nephric tubule, pelvis, ureter and bladder was 0.326, 0.589, 0.602 and 0.735, and that of TLR4 was 0.223, 0.327, 0.379, 0.365, respectively. The mean TLR2 mRNA copy was significantly higher than TLR4 in each tissue (P
