Free vascular endothelial growth factor and its soluble receptor in peritoneal fluid from endometriosis patients
- VernacularTitle:子宫内膜异位症患者腹腔液中血管内皮生长因子及其可溶性受体的测定
- Author:
Shuhong SHI
;
Diangui LI
;
Xiuju MA
- Publication Type:Journal Article
- Keywords:
endometriosis;
vascular endothelial growth factor;
soluble form of VEGFR-1 (s-VEGFR-1/sFlt-1)
- From:Journal of Third Military Medical University
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To better understand the regulation of the soluble receptor of vascular endothelial growth factor (VEGF), s-VEGFR-1 (or soluble fms-like tyrosine kinase, SFlt-1), in angiogenetic process in endometriosis. Methods Levels of free VEGF and s-VEGFR-1 were measured by enzyme-linked immunosorbent assay (ELISA) in peritoneal fluid from 28 subjects with surgically confirmed endometriosis, and 10 controls with no clinical evidence of the disease and other diseases. Meanwhile, we calculated a VEGF activity index by means of the ratio VEGF/s-VEGFR-1. Results We found higher VEGF concentration in endometriotic lesions than controls (P0.05). VEGF activity index in controls, stage Ⅰ-Ⅱ and stages Ⅲ-Ⅳ of endometriosis was 0.310, 0.276 and 0.273, respectively. VEGF and s-VEGFR-1 concentration were also higher in proliferative phase than in secretory phase in endometriotic lesions (P
