Protective effect of medicinal serum of Jiangtang compound recipe on oxidative-injured endothelial cells
- VernacularTitle:降糖复方含药血清对氧化损伤内皮细胞的保护作用
- Author:
Weijia HUANG
;
Guanzhong WU
- Publication Type:Journal Article
- Keywords:
Jiangtang compound recipe;
medicinal serum;
vascular endothelial cells;
oxidative injury
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the protective effect of medicinal serum of Jiangtang compound recipe on endothelial cells which were damaged by H2O2. METHODS: The effects of medicinal serum of Jiangtang compound recipe on cell viability, concentration of malondialdehyde (MDA), NO, endothelin-1 (ET-1) and activity of superoxide dismutase (SOD) were determined for human umbilical vein endothelial cells (ECV304) damaged by H2O2. RESULTS: The medicinal serum of Jiangtang compound recipe significantly improved the structural change of ECV304 cells damaged by H2O2, suppressed the production of MDA and the content of ET-1, increased activity of SOD and the rate of animate cells, and promoted secretion of NO. CONCLUSION: The medicinal serum of Jiangtang compound recipe can resist the injury of ECV304 caused by H2O2, playing a role in the protective effect.
