Effect of garlicin on protecting nonalcoholic fat liver in SD rats induced by high fat diet
- VernacularTitle:大蒜素对高脂饮食诱发大鼠非酒精性脂肪肝的保护作用
- Author:
Liang SHAO
;
Zhen HAN
;
Wanchun WU
;
Chiyi HE
- Publication Type:Journal Article
- Keywords:
garlicin;
nonalcoholic fat liver disease;
lipid preoxidation;
endotoxin
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect of garlicin on protecting nonalcoholic fat liver in rats induced by high fat diet and explore the pathogenesis involved. METHODS: According to the dosage of garlicin and diet, fifty SD rats were randomly divided into five equal groups: normal control group, model control group and garlicin (10, 20, 30 mg/kg) groups. Apart from the rats in normal control group, the rats were all fed with high fat and high cholesterol diet. After 12 weeks, the levels of serum endotoxin (ETX), total cholesterols (TC), triglyceride (TG), superoxide dismutase (SOD), malondialdehyde (MDA), transaminase and free fatty acids (FFA) were detected. The levels of MDA, SOD, glutathione hormone (GSH) in hepatic tissue were also detected. Then the features of live pathology were observed. RESULTS: The levels of ETX, TC and TG in garlicin groups were significantly lower than those in model control group (P
