The role of protein kinase CK2 in signaling transduction and tumourigenesis
- VernacularTitle:蛋白激酶CK2在信号转导中的作用及其与肿瘤发生的关系
- Author:
Jie RUAN
;
Xinguang LIU
;
Nianci LIANG
- Publication Type:Journal Article
- Keywords:
protein kinase CK2;
signaling transduction;
tumourigenesis
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Protein kinase CK2 is a ubiquitously expressed protein serine/threonine kinase present in all eukaryotes. It can intervene transversally into a multitude of signal pathways.It plays a key role in regulation of cell growth and apoptosis in a hierarchical and vertical manner. It was demonstrated that modest deregulation in the CK2 expression impacts a potent oncogenic potential to the cells.Moreover,inhibition of CK2 with specific chemical inhibitors or CK2-targeting antisense RNA may result in depression of tumor. Thus, studying the regulation mechanism of CK2 in tumorigenesis and developing new anti-cancer drugs by employing specific strategies against CK2 are of significant clinical value.
