Effect of polydatin on protein kinase C activity of myocardial cells in ischemia and hypoxia
- VernacularTitle:虎杖苷对缺血缺氧下心肌细胞蛋白激酶C的影响
- Author:
Yuegang WANG
;
Chunhua JIN
;
Pingsheng WU
- Publication Type:Journal Article
- Keywords:
polydatin;
myocardial cells;
ischemia;
hypoxia;
protein kinase C
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the mechanism of polydatin (PD) treating shock through investigating influence of PD in protein kinase C (PKC) activity of myocardial cells when myocardial cells are treated by ischemia and hypoxia. Methods The hypoxia model was set up by drawing off the oxygen of an enclosed acryl glass box and ischemia model by low sugar culture medium.The activity of PKC was measured by ?-scintillation counter. Results The activity of PKC of myocardial cells cytoplasm in normal situation after the cells were treated by PD decreased(vs normal group P0.05). Conclusion PD antagonizes the damage by reversing the PKC activities, which is associated with the anti-shock effect of PD.
