Role of droperidol in modulation of dopamine on central painful sense in morphinistic rats
- VernacularTitle:氟哌利多影响DA对吗啡成瘾大鼠痛觉的调制
- Author:
Ying ZHANG
;
Jie SU
;
Manying XU
- Publication Type:Journal Article
- Keywords:
dopamine;
caudate nucleus;
pain excitation neurons
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the effect of dopamine (DA) and its antagonist on the electrical activities of pain excitation neurons (PEN) in the caudate nucleus (Cd) of morphine dependent rats. Methods The right sciatic nerve was stimulated by train of electrical impulses as noxious stimuli to morphine dependent rats.The electrical discharges of PEN in Cd were recorded with glass microelectrode to observe influences of intracerebroventricular (icv) injection of DA and droperidol on the electrical activities of PEN. Results DA could decrease excitabilities of PEN in Cd of morphine dependent rats. Conclusion Results suggest that the depression of DA on PEN response in Cd of morphine dependent rats might be blocked by droperidol.
