Effects of vigabatrin on absence-like seizures and tonic convulsions in spontaneously epileptic rats
- VernacularTitle:氨己烯酸对自发性癫痫大鼠小发作和大发作的作用
- Author:
Hongguang NIE
;
Jiqun CAI
;
Weifan YAO
- Publication Type:Journal Article
- Keywords:
vigabatrin;
spontaneously epileptic rat;
absence-like seizures;
tonic convulsions
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study effects of vigabatrin on absence-like seizures and tonic convulsions in spontaneously epileptic rats (SERs). Method Electrcorticogram and depth electroencephalographic activity in hip- pocampus of SERs were recorded with implanted electrodes after administration of vigabatrin. Results The number of absence-like seizures was significantly reduced from 100% to (54?5)%, (41?9)% and (34?4)% (P
