Association of human leukocyte antigen DP and DQ with postpartum thyroiditis:an analysis of 52 cases
- VernacularTitle:产后甲状腺炎与HLA-DP HLA-DQ相关性52例分析
- Author:
Meng ZHANG
;
Chenyang LI
;
Ying TENG
- Publication Type:Journal Article
- Keywords:
Thyroiditis,postpartum;
Allele;
HLA-DP antigen;
HLA-DQ antigen
- From:
Chinese Journal of Practical Internal Medicine
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the genetic susceptibility in patients with postpartum thyroiditis(PPT)by genotyping their human leukocyte antigen(HLA)-DP and -DQ alleles.Methods The polymerase chain reaction-sequence based typing(PCR-SBP)method was used to analyze the distribution of HLA-DPA1,HLA-DPB1,HLA-DQA1 and HLA-DQB1 alleles among 52 PPT patients(31 clinical patients,21 subclinical patients)and 82 healthy controls.Compare the allele frequencies between various patient groups and the control population.Results There was no significant difference between patient group and control group.Conclusion Perhaps PPT is not associated with HLA-DP and HLA-DQ alleles.
