Experimental studies on bone defect reconstruction of dog radius using injectable osteoinductive material with fibrin sealant as vehicles
- VernacularTitle:以纤维蛋白胶为载体的注射型骨修复材料修复犬桡骨骨缺损的实验研究
- Author:
Geng CUI
;
Jie LI
;
Wei LEI
- Publication Type:Journal Article
- Keywords:
fibrin tissue adhesive;
bone morphogenetic proteins;
fibroblast growth factor, basic;
bone defects;
bone substitutes
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of injectable osteoinductive materials with fibrin sealant as the vehicle on the reconstruction of segmental radius defect in dog, and to provide an experimental foundation for its clinical application in the future. Methods 20mm bone defects were created in the radius 18 dogs, and in the experiment group b [FS+bFGF+bBMP (bovine BMP)] composite, and in experiment group r (FS+bFGF+rhBMP-2) were injected percutaneously into the defects. A control group (FS) with bone defect only was also included. The reconstruction effect on the segmental dog radius defects was evaluated by radiography, histology, bone mineral density (BMD) at 4, 8, 12, 16, 20 and 24 weeks after operation. Results In the experimental groups with bovine BMP as osteoinductive agent, higher repairing capability and osteogenesis rate were observed in experiment group b (FS+bFGF+bBMP) compared with that of control group (P
