Studies on the protection mechanism of glucocorticoids against the inflammatory injury of vascular endothelial cells
- VernacularTitle:糖皮质激素对血管内皮炎性损伤的保护机制
- Author:
Xingyou WANG
;
Hangwei CHEN
;
Guisheng QIAN
- Publication Type:Journal Article
- Keywords:
glucocorticoids;
endothelium, vascular;
lipopolysaccharides;
apoptosis
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the protection mechanism of glucocorticoids (GC) against the inflammatory injury of vascular endothelial cells (VEC). Methods An inflammatory injury model of VEC was reproduced by treating the human umbilical vein endothelial cells (HUVEC) with lipopolysaccharides (LPS) in vitro. The effect of dexamethasone (Dex) on apoptosis of HUVEC and the release of IL-6 and sICAM-1 of HUVEC was observed, and then the effect of RU486 (an antagonist for glucocorticoid receptor) on reversing the effect of Dex was also observed. Results LPS could induce apoptosis of HUVEC, and the apoptosis rate reached 36.7%?3.9%. On the other hand, glucocorticoid (Dex) could obviously inhibit the apoptosis of HUVEC in LPS, and the apoptosis rate was reduced to 13.2%?0.9%. The difference between the apoptosis rate between these two groups was very significant (P
