Healing mechanism of growth hormone and fibrin glue on intestinal anastomosi in intra-abdominal sepsis rats
- VernacularTitle:生物蛋白胶联合生长激素对腹腔感染后肠吻合口愈合的影响机制
- Author:
Yang BAO
;
Yousheng LI
;
Jie MA
;
Guiqin SUN
;
Jieshou LI
- Publication Type:Journal Article
- Keywords:
Intra-abdominal sepsis;
Growth hormone;
Fibrin glue;
Wound healing
- From:
Parenteral & Enteral Nutrition
1997;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the mechanism of combined growth hormone and fibrin glue on early healing of intestinal anastomosis in intra-abdominal sepsis rats.Methods: Male Wistar rats of abdominal sepsis were randomized into 3 groups.Control rats were given intestinal anastomosis after intestinal fistula operation.Glue group was given intestinal anastomosis and fibrin glue after intestinal fistula.GH group was given intestinal anastomosis and fibrin glue and growth hormone after intestinal fistula.FN,?-SMA,VEGF,and apoptosis in anastomoses were measured.Results: Expression of intestinal FN,?-SMA,and VEGF in GH group were higher than those in other groups and apoptosis were lower than others.Conclusion: It is indicated that combined growth hormone and fibrin glue ameliorates healing of intestinal anastomosis in intra-abdominal sepsis rats.
