Change in the collagen metabolic markers of ischemic cardiomyopathy and its clinical significance
- VernacularTitle:缺血性心肌病胶原代谢标志物的改变及其临床意义
- Author:
Mingjiang LI
;
Yanhong TANG
;
Congxin HUANG
- Publication Type:Journal Article
- Keywords:
Myocardial ischemia;
Myocardial disease;
Collagen metabolism;
Biomarker;
Metalloproteinase
- From:
Chinese Journal of Practical Internal Medicine
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pathological contribution of serological markers of collagen metabolism including matrix-metalloproteinases(MMPs)and its tissue inhibitors(TIMPs),the markers for type I collagen degradation(ICTP)and synthesis(PICP)to cardiac remodeling of ischemic cardiomyopathy(ICM)as well as the pharmacological regulation effect.Methods Plasma levels of MMP-9,TIMP-1,ICTP and PICP were determined by ELISA and RIA in 86 consecutive ICM patients and 25 age-matched control subjects.Patients were divided into two subgroups according to ACEI-taking or not.Echocardiography were performed in all cases.Results The plasma concentration of MMP-9、TIMP-1 and MMP-9/TIMP-1 was significantly increased in ICM group(all P
