Association of-866G/A polymorphism in uncoupling protein 2 gene of patients with type 2 diabetes in Nanjing
- VernacularTitle:南京地区2型糖尿病患者解偶联蛋白2基因-866G/A多态性与胰岛功能相关性研究
- Author:
Xujun SHEN
;
Dalong ZHU
;
Guoyu TONG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,non-insulin-dependent;
Uncoupling protein 2;
Single nucleotide polymrphism;
B-cell function
- From:
Chinese Journal of Practical Internal Medicine
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the assiociation of-866G/A polymorphism in the promoter of uncoupling protein 2(UCP2)gene in patients with type 2 diabetes and B-cell function in Han population in Nanjing.Methods For the case-control study,PCR-RFLP method was used to determine the distributions of allele and genotype frequencies of-866G/A polymorphism in the human UCP2 gene in 229 type 2 diabetic patients and 196 normal control subjects.All of the testees accepted oral glucose tolerance test and insulin releasing test to detect B-cell secretion function and insulin sensitivity.Results The distribution of genotype and allele frequencies of-866G/A polymorphism in the promoter of the human UCP2 gene were significantly different between type 2 diabetic patients and normal control subjects(?2=6.555,P=0.038;?2=6.363,P=0.012 respectively).The frequency of A/A genotype and A allele in type 2 diabetic were significantly higher than that in contrast(OR=1.99,OR=1.42 respectively,both P
