The cough reflex sensitivity and airway neurogenic inflammation in patients with cough post infectious
- VernacularTitle:感冒后咳嗽敏感性及气道神经源性炎症改变
- Author:
Ruchong CHEN
;
Chunli LIU
;
Wei LUO
- Publication Type:Journal Article
- Keywords:
Cough;
Cough post infectious;
Cough reflex sensitivity;
Neurogenic inflammation;
Pathogenesis
- From:
Chinese Journal of Practical Internal Medicine
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of the cough reflex sensitivity and airway neurogenic inflammation in the pathogenesis of cough post infectious(CPI).Methods Capsaicin provocation test and sputum inducing were performed in 10 patients with CPI(CPI group)and 10 healthy subjects(normal control group)to detect the cough reflex sensitivity and neurokinin of sputum.Total and differential cells count of induced sputum was performed.Substance P(SP),neurokinin A(NKA),neurokinin B(NKB)and calcitonin gene-related peptide(CGRP)in the supernatant of induced sputum were measured.The expression of SP,neurokinin 1 receptor and NKA in sputum cells was detected.Results The cough threshold(lg C5)of CPI was significantly lower than normal(1.16?0.61 vs 2.64?0.28,P
