Expression of IRS-2 in the Liver of High Fat and Sugar Diet Induced NAFL Mice
- VernacularTitle:高脂高糖诱导的非酒精性脂肪肝小鼠肝胰岛素底物受体-2的表达
- Author:
Cong LIU
;
Yijun ZHOU
;
Li LI
- Publication Type:Journal Article
- Keywords:
Fatty liver;
Insulin receptor substrate-2;
Diabetes
- From:
Chinese Journal of Practical Internal Medicine
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of insulin receptor substrate-2(IRS-2)in the liver of nonalcoholic fatty liver(NAFL)mice.Methods Ten female C57BL6J mice fed with normal diet were served as controls,while fifteen fed with high fat and sugar diet for either 8 weeks(group-A)or 16 weeks(group B)were as NAFL mice models.Abdominal fat mass,total cholesterol(TC),triglycerides(TG),high density lipoprotein cholesterol(HDL-C),fasting blood glucose(FBG)insulin(INS)and liver function,liver weight were measured.And the expression of IRS-2 and the content of lipid in the liver were also detected.Results The abdominal fat mass serum TC,and FBG were significantly higher in high fat and sugar diet fed mice than that in controls(P
