Effect of benidipine on NO and ET-1 of patients with coronary heart diease
- VernacularTitle:贝尼地平对冠心病患者一氧化氮和内皮素的影响
- Author:
Li WEI
;
Xueqi LI
;
Lan ZHANG
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Benidipine;
NO;
ET-1
- From:
Chinese Journal of Practical Internal Medicine
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To search for the effect of benidipine,a kind of Ca2+ blocker,on NO and ET-1 of patients with coronary heart disease.Methods Benidipine(2~4 mg/d)were given to the patients with coronary heart disease diagnosed definitely for 8 weeks.Forty healthy candidates were enrolled in the control group,and their morning fasting blood were tested for NO and ET-1 levels at the 4th,8th week in order to compare with the control group.Results Blood NO level of CHD patients was lower and blood ET-1 level was higher than the control group remarkably.After treatment NO level was increased and ET-1 level was decreased separately.Conclusion Benidipine can increase NO level and decrease ET-1 level,which demonstrated the protective effect of benidipine for endothelia.
