Changes of IL-18 and Th1/Th2 in serum of lung cancer patients and their relationship with tumor staging
- VernacularTitle:肺癌患者外周血Th1/Th2细胞因子及IL-18水平变化与肿瘤分期的关系
- Author:
Yanqiu LI
;
Jianchun LI
;
Hongquan GUAN
;
Yuwen CAI
- Publication Type:Journal Article
- Keywords:
lung cancer;
IL-18;
Th1/Th2;
cytokines
- From:Journal of Third Military Medical University
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the levels of IL-18,Th1(IL-2,TNF-?) and Th2(IL-4,IL-10) in patients with lung cancer and their relation to clinical pathological stages.Methods Totally 109 lung cancer patients were of 45 squamous cancer,40 adenocarcinoma,18 small cell lung cancer and 6 large cell carcinoma.Serum levels of IL-18,TNF-?,IL-2,IL-4 and IL-10 were determined by using an ELISA assay in 109 lung cancer patients and in 30 normal people.Results The levels of IL-18,TNF-? and IL-2 were significantly lower and the levels of IL-4 and IL-10 were significantly higher in lung cancer patients than in controls(P
