Tetrandrine induces and sensitizes vascular smooth muscle cell apoptosis in renovascular hypertensive rats
- VernacularTitle:粉防己碱促进和敏化肾性高血压大鼠血管平滑肌细胞凋亡
- Author:
Li ZHANG
;
Changping ZHANG
;
Qingping LI
- Publication Type:Journal Article
- Keywords:
renovascular hypertension;
vascular remodeling;
vascular smooth muscle cell;
apoptosis;
tetrandrine
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
1999;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To determine whether apoptosis is involved in the development of vascular remodeling in renovascular hypertension rats and whether the inhibitory effect of tetrandrine on proliferation is mediated by apoptosis.METHODS:Apoptosis was detected in histologic sections of aorta and tail arteries with in situ end-labeling.The apoptosis ratio in cultured cells was measured by [3H]-TdR incorporation and flow cytometer analysis method.RESULTS:Compared with the sham group,the apoptosis rate of renal hypertension rat(RHR)increased.Tetrandrine(Tet)directly induced apoptosis in cultured AVSMCs(from RHR)and increased apoptosis induced by TGF?,TGF?1 and deficient FCS.CONCLUSION:Tet induces and sensitizes vascular smooth muscle cells of RHR to apoptosis,which at least partly related to the regression of vascular remodeling.
