Research progresses of RNA interference
- VernacularTitle:RNA干扰技术的研究进展
- Author:
Yuxin QIN
;
Linghua MENG
;
Jian DING
- Publication Type:Journal Article
- Keywords:
RNAi;
siRNA;
miRNA;
RISC;
Dicer;
gene silencing
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
RNA interference is an evolutionarily conserved surveillance mechanism that responds to double-stranded RNA by sequence-specific silencing of homologous genes. Although it is a short time since the discovery of the phenomenon, the technology develops fastly for the character of easy operation, low investment, specificity and potentiality, and researchers have made some progress on the mechanism of RNA interference and application in functional genomics and disease treatment. This article reviews the history, mechanism, biological significance and application of RNA interference.
